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Quality in Laboratory Hemostasis and Thrombosis

Quality in Laboratory Hemostasis and Thrombosis by Steve Kitchen
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Contributors, vii

Foreword, x

Preface, xii

Steve Kitchen, John D. Olson, & F. Eric Preston

Part 1: General Quality Program

1 General quality planning in the hemostasis laboratory, 3
John D. Olson

2 Hemostasis test validation, performance, and reference intervals: international recommendations and guidelines, 12
Richard A. Marlar

3 Causes of errors in medical laboratories, 22
Giuseppe Lippi & Emmanuel J. Favaloro

4 International standards in hemostasis, 32
Trevor W. Barrowcliffe & Anthony R. Hubbard

5 Sample integrity and preanalytical variables, 45
Dorothy (Adcock) Funk

6 Internal quality control in the hemostasis laboratory, 57
Steve Kitchen, F. Eric Preston, & John D. Olson

7 External quality assessment in hemostasis: its importance and significance, 65
F. Eric Preston, Steve Kitchen, & Alok Srivastava

8 The unique challenges of hemostatic testing in children, 77
M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, & Anthony K.C. Chan

Part 2: Quality in Coagulation Testing

9 Initial evaluation of hemostasis: reagent and method selection, 95
Wayne L. Chandler

10 Assay of factor VIII and other clotting factors, 105
Steve Kitchen & F. Eric Preston

11 Application of molecular genetics to the investigation of inherited bleeding disorders, 115
Stefan Lethagen, Morten Dunø, & Lars Bo Nielsen

12 Detecting and quantifying acquired functional inhibitors in hemostasis, 124
Bert Verbruggen, Myriam Dardikh, & Britta Laros-van Gorkom

13 Standardization of d-dimer testing, 136
Guido Reber & Philippe de Moerloose

14 Point-of-care testing in hemostasis, 147
Chris Gardiner, Dianne Kitchen, Samuel Machin, & Ian Mackie

Part 3: Quality in Testing for Platelet Function and von Willebrand Disease

15 Diagnostic assessment of platelet function, 159
Paquita Nurden, Alan Nurden, & Martine Jandrot-Perrus

16 Laboratory evaluation of heparin-induced thrombocytopenia, 174
Theodore (Ted) E. Warkentin & Jane C. Moore

17 Laboratory evaluation of von Willebrand disease: phenotypic analysis, 192
Emmanuel J. Favaloro

18 Laboratory analysis of von Willebrand disease: molecular analysis, 204
Anne C. Goodeve & Ian R. Peake

Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation

19 Quality issues in heritable thrombophilia testing, 219
Isobel D. Walker & Ian Jennings

20 Evaluation of antiphospholipid antibodies, 233
Michael Greaves

21 Monitoring heparin therapy, 244
Marilyn Johnston

22 Monitoring oral anticoagulant therapy with vitamin K antagonists, 253
Armando Tripodi

23 Monitoring new anticoagulants, 264
Elaine Gray & Trevor W. Barrowcliffe

Index, 273

Wiley; February 2013
296 pages; ISBN 9781118543498
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Title: Quality in Laboratory Hemostasis and Thrombosis
Author: Steve Kitchen; John D. Olson; F. Eric Preston
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