Challenges and Practices for the Pharmaceutical and Fine Chemical Industries
Opens the door to the sustainable production ofpharmaceuticals and fine chemicals
Driven by both public demand and government regulations,pharmaceutical and fine chemical manufacturers are increasinglyseeking to replace stoichiometric reagents used in synthetictransformations with catalytic routes in order to develop greener,safer, and more cost-effective chemical processes. This booksupports the discovery, development, and implementation of newcatalytic methodologies on a process scale, opening the door to thesustainable production of pharmaceuticals and fine chemicals.
Pairing contributions from leading academic and industrialresearchers, Sustainable Catalysis focuses on key areas thatare particularly important for the fine chemical and pharmaceuticalindustries, including chemo-, bio-, and organo-catalytic approachesto CH, CN, and CC bond-forming reactions.Chapters include academic overviews of current innovations andindustrial case studies at the process scale, providing newinsights into green catalytic methodologies from proof-of-conceptto their applications in the synthesis of target organicmolecules.
Sustainable Catalysis provides the foundation needed todevelop sustainable green synthetic procedures, with coverage ofsuch emerging topics as:
- Catalytic reduction of amides avoiding LiAlH4 or B2H6
- Synthesis of chiral amines using transaminases
- Industrial applications of boric acid and boronic acidcatalyzed direct amidation reactions
- CH activation of heteroaromatics
- Organocatalysis for asymmetric synthesis
Offering a balanced perspective on current limitations,challenges, and solutions, Sustainable Catalysis isrecommended for synthetic organic chemists seeking to develop newmethodologies and for industrial chemists dedicated to large-scaleprocess development.
440 pages; ISBN 9781118354513
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Title: Sustainable Catalysis
Author: Peter J. Dunn; K. K. (Mimi) Hii; Michael J. Krische; Michael T. Williams