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Apoptosis in Toxicology is the first book to focus on the molecular regulation of apoptosis with particular emphasis on toxicant action. Cell survival signalling and its perturbation is addressed at the genetic and biochemical level, including key survival and death genes, survival signalling, commitment to apoptosis and recruitment of the initiator and executioner caspases.Emphasis is given to the role apoptosis plays in the action of toxicants in the brain, the immune system, the reproductive organs, the kidney and the liver. The ability of drugs to regulate apoptosis either as a target or as an adverse effect is discussed with particular reference to cancer chemotherapy. The many methods that can be employed to quantify apoptosis are compared and their application to different tissues is discussed.
This timely and comprehensive volume has been written by leading authorities and active researchers in their respective fields. It will have broad appeal to toxicologists, physicians and biologists across many disciplines.
CRC Press; December 1999
248 pages; ISBN 9781135735258
Read online, or download in secure PDF format or MobiPocket
248 pages; ISBN 9781135735258
Read online, or download in secure PDF format or MobiPocket
Subject categories
- Academic > Life Sciences > Biology > Cytology
- Medical > Toxicology
- Science > Cytology
ISBNs
9781135735302
9781135735296
9781135735258
9780748408153
9780203484500
0203484509