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About the author
Emanuela Corsini is associate professor of Toxicology at the School of Pharmacy of the University of Milan (Italy), where she heads the Laboratory of Immunotoxicology and Immunopharmacology. She obtained her PhD in Food and Environmental Toxicology in 1993 at the University of Milan. Dr. Corsini's research program encompasses distinct areas of immunotoxicology, including the understanding of the molecular mechanisms of action of immunotoxic/immunomodulatory compounds on both innate and adaptive immunity. She is active in numerous scientific and professional organizations, serves on several editorial boards of Toxicology journals. From 2009-2013 she was Member of EUROTOX Education Sub Committee, from 2005-2011 she was the Chair of the Immunotoxicology and Chemical Specialty Section at EUROTOX, and from 2010 she is one of the Director of the IUTOX Executive Committee.
Henk van Loveren did his PhD (tumor immunology) at Utrecht University in 1981 and was post-doctoral fellow (immunology) at Yale University, New Haven CT, USA in 1982. Since 1984, he is at the National Institute of Public Health and the Environment in Bilthoven, the Netherlands, where he has run the Immunotoxicology program and is now Senior Scientific Advisor to the Centre of Health Protection. In addition, he is also Professor of Immunotoxicology at Maastricht University in the Netherlands. His research has been devoted to the development of immunotoxicity testing, being performed in cell systems, in laboratory animals and clinical settings. Recent developments are the implementation of toxicogenomics in immunotoxicity testing. He has been member of several advisory committees, in addition to being director of the WHO Collaborating Centre for Immunotoxicology and Allergic Hypersensitivity. Prof. van Loveren was one of the founders of the Immunotoxicology and Chemical Specialty Section at EUROTOX and served as its president from 2000-2003. For his achievements, he got the Vos Career Achievement Award Immunotoxicology of the American Society of Toxicology in 2008, and the Merit Award 2010 of the European Federation of Toxicology Societies.
The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered.
Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models.
Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
; July 2014
420 pages; ISBN 9783527676996Read online
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Title: Molecular Immunotoxicology
Author: Emanuela Corsini; Henk Van Loveren
The Evolution of Immunotoxicology
Overview on the Mechanisms Underlying Chemical-Induced Immunotoxicity
Use of Toxicogenomics in Immunotoxicology
Breakdown of the Molecular Processes Driving the Adverse Outcome Pathways (AOPs) of Skin and Respiratory Sensitization Induction in Humans Exposed to Xenobiotics and Proteins
Chemical allergen-induced skin cell activation
The Aryl Hydrocarbon Receptor (AHR) as a Mediator of Adverse Immune Reactions
Immunotoxicological Effects of Pharmaceuticals on Signal Transduction in Innate and Adaptive Immunity
Promises and challenges with immunomodulatory biologics
The Non-Clinical Evaluation of Biotechnology-Derived Pharmaceuticals, Moving on after the TeGenero case
Particulate matter-induced immune activation
Genotoxic Mechanisms of PAH-Induced Immunotoxicity
Immunotoxic Effects of Perfluoroalkylated Compounds: Mechanisms of Action
Pesticide-Induced Immunotoxicity: Molecular Targets
Mode of Action of Organotins in Immune Cells