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Introduction to the Principles of Drug design and Action
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As knowledge of biological systems has expanded and the number of techniques available for exploring and visualising their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionised the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated.
The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolised to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from programme sanction to clinical trials
