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The hERG Cardiac Potassium Channel

Structure, Function and Long QT Syndrome

The hERG Cardiac Potassium Channel by Novartis Foundation
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This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. 

It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. 

Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

Wiley; June 2005
309 pages; ISBN 9780470021415
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Title: The hERG Cardiac Potassium Channel
Author: Novartis Foundation
 
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ISBNs
0470021411
9780470021408
9780470021415
9780470668719