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Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents
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Due to the strong link between cyclin-dependent kinases and cancer, CDKs are being investigated as possible targets for therapeutic intervention. Providing unparalleled coverage, top researchers describe CDK involvement in cell cycle control, the structures of CDKs and their respective cyclins, and their association characteristics. They also examine selectivity, activation, and biological inhibitors. The first section provides a conceptual framework; the second focuses on CDK inhibitors as functional anticancer agents; the third provides an up-to-date account of small molecule CDK inhibitors from leading world laboratories. It concludes with perspectives for the future.
