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Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents

Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents by Paul J. Smith
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INTEGRATION OF CELL CYCLE CONTROL PATHWAYS AND THE OPPORTUNITIES FOR TARGETING
Cell Cycle Dynamics and the Challenges for CDK Targeting
Paul J. Smith, Emeline Furon, and Rachel J. Errington
Functional Regulation of CIP/KIP CDK Inhibitors
Mong-Hong Lee and Ruiying Zhao
Mouse Models to Study the In Vivo Function of Cyclin-Dependent Kinases in Normal Homeostasis and Tumor Development
Marcos Malumbres, Pierre Dubus, and Sagrario Ortega
Cyclin-Dependent Kinase Inhibitors and Vascular Disease
Martin F. Crook and Manfred Boehm
CDK INHIBITORS: TARGETS AND THEIR EVALUATION
Evaluation of CDK Inhibitor Selectivity: From Affinity Chromatography to Yeast Genetics
Stéphane Bach, Marc Blondel, and Laurent Meijer
Development of CDK Inhibitors as Anticancer Agents: From Rational Design to CDK4-Specific Inhibition
Sachin Mahale and Bhabatosh Chaudhuri
Three-Dimensional Structures of Cyclin-Dependent Kinases and Their Inhibitor Complexes
Ursula Schulze-Gahmen and Sung-Hou Kim
CDK INHIBITORS: CHEMISTRY FOCUS
Cyclin-Dependent Kinase Small Molecule Modulators for Cancer Therapy
Adrian M. Senderowicz
(R)-Roscovitine (CYC202, Seliciclib)
Laurent Meijer, Karima Bettayeb, and Hervé Galons
Development, Selectivity, and Application of Paullones, a Family of CDK Inhibitors
Conrad Kunick, Thomas Lemcke, and Laurent Meijer
Discovery of BMS-387032, a Potent Cyclin-Dependent Kinase Inhibitor in Clinical Development
John T. Hunt
Oxindole Inhibitors of Cyclin-Dependent Kinases as Antitumor Agents
Philip A. Harris
Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors
David J. Carini, Catherine R. Burton, and Steven P. Seitz
Development of Indolocarbazoles as Cyclin D1/CDK4 Inhibitors
Guoxin Zhu
Pyrazoles as Efficient Adenine-Mimetic Heterocycles for the Discovery of CDK Inhibitors
Paolo Pevarello and Anna Vulpetti
Pyrazolo [3,4-d] pyrimidin-4-ones: Exploring the Structural Determinants of Potency and Selectivity in Cyclin-Dependent Kinase Inhibition
Jay A. Markwalder and Steven P. Seitz
THERAPEUTIC PERSPECTIVE
Cyclin-Dependent Kinase Inhibitors and Combination Therapy: Experimental and Clinical Status
Lloyd R. Kelland
CDK Inhibitors as Anticancer Agents: Perspectives for the Future
Jayalakshmi Sridhar, Nagarajan Pattabiraman, Eliot M. Rosen,
and Richard G. Pestell
INDEX
CRC Press; October 2006
476 pages; ISBN 9781420005400
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Title: Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents
Author: Paul J. Smith; Eddy W. Yue
 
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