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Sequence Comparison
Theory and Methods
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Biomolecular sequence comparison is the origin of bioinformatics. Today, powerful sequence comparison methods, together with comprehensive biological databases, have changed the practice of molecular biology and genomics. This in-depth, state-of-the-art study of sequence alignment and homology search, covers the full spectrum of the field - from alignment methods to the theory of scoring matrices and alignment score statistics. Following a comprehensive introduction, this useful text/reference focuses on algorithms and techniques, as well as discusses the theory. This easy-to-follow text examines alignment methods and techniques, features a new issue of sequence comparison (the spaced-seed technique), addresses several new flexible strategies for coping with various scoring schemes, and covers the theory on the significance of high-scoring segment pairs between two unalignment sequences.Useful appendices are provided for basic concepts in molecular biology, primer in statistics and software for sequence alignment. The book is written for readers with little or no knowledge of biology, algorithms and probability.
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