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Strategies in Antiviral Drug Discovery
This book captures the state of the science with twenty reviews that examine the latest in todays antiviral drug discovery efforts. The introduction of nucleoside analogs and investigations of novel antiviral targets have brought significant new possibilities to the field. These reviews range from in-depth analyses of a specific viral target, to examination of multiple targets in medically important viruses. All chapters include the authors thoughts regarding future developments in their specific topic, and the book concludes with an Afterword in which several experts consider the general future of antiviral drug discovery.With its coverage of many different types of viruses including influenza virus, herpesvirus, the SARS coronavirus, orthopox- and flaviviruses, hepatitis C virus, and a wide range of topics in HIV-1, Antiviral Research offers investigators a broad view of the current state of nucleoside analogs and other antiviral strategies. This book is certain to help stimulate new ideas and approaches for virologists, biochemists, pharmaceutical chemists, and other investigators.Key Features Covers a broad range of viruses, including HIV-1, HSV, and HCV Presents the fundamental principles of antiviral agents and forecasts future possibilities Investigates novel enzyme and protein inhibitors Analyzes clinical aspects of viral infection with regard to treatment and toxicity Examines known and potential targets at all stages of viral development International author group represents both academia and industry Contents1. Antiherpesviral DNA Polymerase Inhibitors Donald M. Coen2. Entry Inhibitors of Human Immunodeficiency Virus Masanori Baba3. Human Immunodeficiency Virus Type 1 Non-Nucleoside Reverse Transcriptase Inhibitors Dirk Jochmans, Johan Vingerhoets, Eric Arnoult, Luc Geeraert, and Jérôme Guillemont4. Nucleoside Analogue Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase Jérôme Deval and Matthias Götte5. Integrase as a Novel Target for the Inhibition of Human Immunodeficiency Virus Type 1 Infection: Current Status and Future Perspectives Linos P.R. Vandekerckhove, Frauke Christ, Zeger Debyser, Andrew Owen, David Back, Arnout Voet, Jonathan Schapiro, and Dirk Vogelaers6. Human Immunodeficiency Virus Type 1 Tat and Rev as Potential Targets for Drug Development Sergei Nekhai and Kuan-Teh Jeang7. Inhibitors of the Human Immunodeficiency Virus Protease Jorge L. Martinez-Cajas and Mark A. Wainberg8. Hepatitis C Virus RNA-Dependent RNA Polymerase as a Target for Antiviral Drug Intervention: Non-Nucleoside Inhibitors Yaya Liu, Yupeng He, and Akhteruzzaman Molla9. Nucleoside Analog Inhibitors of Hepatitis C Viral Replication Steven S. Carroll and Robert L. LaFemina10. Antiviral Targets in Orthopoxviruses Mark N. Prichard and Earl R. Kern11. Influenza Virus Antiviral Targets Gillian M. Air and Wayne J. Brouillette12. Developments in the Search for Small Molecule Inhibitors for Treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Dale L. Barnard and Yohichi Kumaki13. Antiviral Treatment of Flaviviruses Justin G. Julander14. Clinical Aspects of Hepatitis C Virus Infection David Durantel and Fabien Zoulim15. Microbicides: Molecular Strategies for Prevention of Sexually Transmitted Viral Disease Raina N. Fichorova16. Phenotypic Susceptibility Assays for Human Immunodeficiency Virus Type 1 Neil T. Parkin, Eoin Coakley, and Christos J. Petropoulos17. Metabolism of Antiviral Nucleosides and Nucleotides Adrian S. Ray and Michael J. M. Hitchcock18. Targeting the Interferon Response for Antiviral Therapy Michael D. Robek19. Toll-Like Receptors: Novel Molecular Targets for Antiviral Immunotherapy Raymund R. Razonable, Albert J. Eid, and Martin Henault20. New Herpes Simplex Virus Replication Targets Sandra K. WellerAfterword: Closing Thoughts Robert L. LaFemina