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  • Quasispecies: Concept and Implications for Virologyby Esteban Domingo

    Springer Berlin Heidelberg 2006; US$ 289.00

    Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations.   more...

  • Virus as Populationsby Esteban Domingo

    Elsevier Science 2015; US$ 99.95

    Virus as Populations: Composition, Complexity, Dynamics, and Biological Implications explains fundamental concepts that arise from regarding viruses as complex populations when replicating in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, probability to be transmitted... more...

  • Origin and Evolution of Virusesby Esteban Domingo; Robert G. Webster; John F. Holland

    Elsevier Science 1999; US$ 255.00

    Are infectious diseases caused by novel entities, viruses that have rapidly evolved into more pathogenic forms, or viruses that have crossed species divides and become more virulent in their alternative host? These questions and how new diseases such as AIDS emerged have prompted renewed interest in the ways viruses originated and co-evolved with their... more...

  • Origin and Evolution of Virusesby Esteban Domingo; Colin R. Parrish; John J. Holland

    Elsevier Science 2008; US$ 190.00

    New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human... more...

  • Quasispecies and RNA Virus Evolutionby Esteban Domingo; Christof K. Biebricher; Manfred Eigen; John J. Holland

    Landes Bioscience 2000; US$ 69.00

    RNA viruses, by virtue of their high mutation rates and large population sizes, from complex mutant distributions termed viral quasispecies. Studies collected here address connections between theoretical quasispecies and real virus quasispecies, and the biological implications of the quasispecies structure of RNA viruses and other simple replicons. more...

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