Science : Biology

"The ADAM Family of Proteases" provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer's amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis. more...

Price: $149.00

Explores the physiological and psychological phenomenon of addiction including the nature of dependence, the dependence potential of drugs, and the importance of motivation. This book considers the use of methadone, buprenorphine, adrenergic agonists, and naltrexone for detoxification. It is useful for those in the field of addiction. more...

Price: $79.95

Recent advances in our understanding of the human brain suggest that adolescence is a unique period of development during which both environmental and genetic influences can leave a lasting impression. To advance the goal of integrating brain and prevention science, two areas of research which do not usually communicate with one another, the Annenberg Public Policy Center's Adolescent Risk Communication Institute held a conference with the purpose of producing an integrated volume on this interdisciplinary area. Presenters/chapter contributors were asked to address two questions: What neurodevelopmental processes in children and adolescents could be altered so that mental disorders might be prevented? And what interventions or life experiences might be able to introduce such changes? The book has a 5-part structure: biological and social universals in development; characteristics of brain and behavior in development; effects of early maltreatment and stress on brain development; effects of stress and other environmental influences during adolescence on brain development; and reversible orders of brain development. The twenty chapters include contributions from some of the most well-known researchers in the area. more...

Price: $37.95

A volume of indispensable methods for the use of transposons and phage in genomic engineering. more...

Price: $175.00

The analysis of phenotypic information is increasing in importance in biological research. This book covers the major themes of the rapidly emerging field of advanced imaging in Biology and Medicine. more...

Price: $219.00