Science : Cytology

Proteins are the principal components of the protoplasm of all cells and, therefore, are essential to life. Changes to the structure of a protein within the cell are brought about by enzymes, which act as catalysts and allow the modification to the protein to take place. A posttranslational modification occurs when an alteration to a polypeptide chain within the protein is made. The remarkable discovery of over 100 of these posttranslational modifications emphasizes the importance of the process of enzymatic reaction to the structure and function of proteins within living cells. This volume examines a number of different proteases, a type of enzyme, that are required in order for the change to a biologically active mature protein to occur. The discussion of these various proteases is rarely undertaken in one volume and will serve as a great resource for scientists studying the group of proteases on signal peptide processing as well as those working on propeptide processing. These areas of research do not normally overlap, and yet they are each of common importance to the same cell processes. more...

Price: $170.00

This volume supplements Volumes 63, 64, 87, and 249 of Methods in Enzymology . These volumes provide a basic source for the quantitative interpretation of enzyme rate data and the analysis of enzyme catalysis. Among the major topics covered are Engergetic Coupling in Enzymatic Reactions, Intermediates and Complexes in Catalysis, Detection and Properties of Low Barrier Hydrogen Bonds, Transition State Determination, and Inhibitors.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. more...

Price: $149.95

This completely revised and expanded new edition provides detailed descriptions and practical guidance for the in vitro cultivation of disparate types of epithelia. In recent years, the uses of epithelial cell culture in cell biology and tissue engineering has increased dramatically. This revision reflects those advances by including new chapters on the culture of animal and human hepatocytes, kidney epithelium, and bladder epithelium. more...

Price: $146.50

This book covers a wide spectrum of areas related to basic bone research. While bone remodeling, bone development, and osteoclast biology constitute the main contents, topics important to the understanding of bone metabolism and treatment of bone-related diseases are also intensively reviewed. Three chapters are dedicated to the classic topic of bone mechanics, which include a brief overview of the mechanostat hypothesis, a more detailed review on mechanotransduction and bone adaptation, and a chapter illustrating the basic principles of bone mechanical testing. New emerging fields such as skeletal stem cells, bone tissue engineering, phytoestrogens applications, and bone genetics study using mouse models, are also covered in detail. The book closes with a special chapter dedicated to state-of-the-art advances in bone biology research. more...

Price: $135.00

Together with other volumes in this series, Volume 58 presents thoughtful and forward-looking articles on developmental biology and developmental medicine. Reviews include:. * A role for endogenous electric fields in wound healing. * The role of mitotic checkpoint in maintaining genomic stability. * The regulation of oocyte maturation. * Stem cells: A promising source of pancreatic islets for transplantation in type 1 diabetes. * Differentiation potential of adipose derived adult stem (ASAS) cells. The exceptional reviews in this volume of Current Topics in Developmental Biology will be valuable to both clinical and fundamental researchers, as well as students and other professionals who want an introduction to current topics in cellular and molecular approaches to developmental biology and clinical problems of aberrant development. more...

Price: $160.00