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- Springer-Verlag Berlin and Heidelberg GmbH & Co. KG 2006; US$ 289.00
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. Major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. more...
- Springer-Verlag Berlin and Heidelberg GmbH & Co. KG 2006; US$ 239.00
The ethiopathologies of autoimmune diseases are complex. A broad variety of cell types and gene products are involved. This book explores clinical and experimental evidence suggesting that the importance of an individual factor changes during the course of the disease. more...
- Springer-Verlag New York Inc 2007; US$ 219.00
Developments made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. This work explains the role and mechanism of DNA repair proteins in somatic hypermutation. more...
- Springer 2006; US$ 99.00
Presents a portrayal of the life and achievements of Georges Kohler, who at age 38 shared a 1984 Nobel Prize with NK Jerne and C Milstein for inventing the technique that generates monoclonal antibodies. This scientific biography explains Kohler's pivotal discovery and its momentous influence on research, medicine and the biotech industry. more...
- Springer 2006; US$ 239.00
TNF-alpha plays a crucial role in the pathogenesis of many chronic inflammatory diseases. Elevated levels of TNF-alpha have been demonstrated in Crohn's disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis, suggesting a role for TNF-alpha in their pathogenesis. Although TNF-alpha plays a critical role in the activation of innate and... more...
- Springer 2006; US$ 219.00
Deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention. This book offers a series of contributions of the various challenging aspects of lymphocyte migration in homeostasis and in disease. more...
- Springer-Verlag Berlin and Heidelberg GmbH & Co. KG 2007; US$ 219.00
There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. These features of CD1 antigen presentation systems now point to a new and expanded view of the natural function of ab T cells, which... more...
- Springer-Verlag New York Inc 2007; US$ 259.00
Focuses on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. This book aims to provide the reader with a survey of the various aspects of Fas biology and the open questions of the field are addressed. It is intended for Ph D and post-doctoral students starting to work in the field. more...
- Elsevier Science 1996; US$ 225.00
This volume is THE definitive, completely up-to-date, reference work for ALL researchers and clinicians working in autoimmunity. Up-to-Date: This is a timely critical review of more than 100 autoantibodies by leading experts in their respective fields, and includes many recent references. International Experts: The 120 Chapters have been written... more...
- Elsevier Science 2007; US$ 205.00
Many of the systemic autoimmune diseases seen in children are different from those seen in adults making them a special problem for physicians and scientists who care for the affected children and study their diseases. Benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties, this volume covers the latest advances... more...