Evolution-adjusted Tumor Pathophysiology:

The Novel Language of Tumor Biology


Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.
  • Springer Netherlands; July 2013
  • ISBN 9789400768666
  • Read online, or download in secure PDF format
  • Title: Evolution-adjusted Tumor Pathophysiology:
  • Author: Albrecht Reichle (ed.)
  • Imprint: Springer