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Signalling Pathways in Apoptosis

Signalling Pathways in Apoptosis by Diane Watters
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Apoptosis, or programmed cell death, is a necessary process by which a cell may die without adversely affecting its environment. It plays a crucial role in normal development, and in the body's defence mechanisms against disease. Too much cell death is destructive, leading to neurodegenerative diseases and impaired development. Conversely, too little cell death can lead to an increased susceptibility to cancer and sustained viral infection. Apoptosis is a matter of balance
Dramatic progress has been made in the study of apoptosis over the past decade. One of the most rapidly expanding knowledge bases being established is on the molecular mechanisms controlled by a variety of gene products including Bcl-2, caspases, death receptors, and proteolytic targets, as well as the central role of the mitochondrion. The major challenge in apoptosis research is how the protein products involved operate in an intricate web of signaling pathways that also play a crucial role in cell proliferation and differentiation. This book concentrates on elucidating these signal transduction mechanisms, an area not properly reviewed by other apoptosis texts.
CRC Press; April 2014
338 pages; ISBN 9781482298215
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Title: Signalling Pathways in Apoptosis
Author: Diane Watters; Martin Lavin
 
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ISBNs
0203303652
9780203303658
9781135296742
9781482298215
9789057023927