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Scale-Up and Optimization in Preparative Chromatography

Principles and Biopharmaceutical Applications

Scale-Up and Optimization in Preparative Chromatography by Anurag Rathore
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Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; data comparisons from all stages of production; and industrial separation schemes for products such as synthetic molecules, antibody fragments, IgG, growth factors, and plasmid DNA. The book covers external constraints, separation economics, correlations for transport and kinetic phenomena, and the configuration and parameters of column design.

CRC Press; September 2002
360 pages; ISBN 9780203909287
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Title: Scale-Up and Optimization in Preparative Chromatography
Author: Anurag Rathore; Ajoy Velayudhan