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TGF [beta] and Cancer

TGF [beta] and Cancer by John R Benson
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TGFb has emerged as a pre-eminent negative growth factor with inhibitory effects upon a range of malignant epithelial cell types. This book will focus on the theme that the malignant phenotype is associated with an imbalance of growth factors and disorders of intercellular communication within the micro-environment of tumor cells. Evidence will be presented suggesting that altered expression of TGFb and/or its receptors directly contributes to neoplastic progression in certain common cancers, including not only those of breast, but also colon, stomach, lung and prostate. The clinical potential for strategies aimed at boosting endogenous levels of TGFb and enhancing response to this negative growth modulator will be discussed at the laboratory-clinical interface.
Landes Bioscience; October 1998
184 pages; ISBN 9781587064333
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Title: TGF [beta] and Cancer
Author: John R Benson