The Leading eBooks Store Online 4,319,012 members ⚫ 1,429,817 ebooks

New to eBooks.com?

Learn more

Predictive Methods in Percutaneous Absorption

Predictive Methods in Percutaneous Absorption by Gary P. Moss
Buy this eBook
US$ 159.00
(If any tax is payable it will be calculated and shown at checkout.)

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models.

The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Springer Berlin Heidelberg; July 2015
206 pages; ISBN 9783662473719
Read online, or download in secure PDF format
Title: Predictive Methods in Percutaneous Absorption
Author: Gary P. Moss; Darren R. Gullick; Simon C. Wilkinson
 
  • News
  • Contents
No entry found