The Leading eBooks Store Online 4,319,012 members ⚫ 1,429,817 ebooks

New to eBooks.com?

Learn more

Agammaglobulinemia

Agammaglobulinemia by Alessandro Plebani
Buy this eBook
US$ 129.00
(If any tax is payable it will be calculated and shown at checkout.)

This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammaglobulinemia, caused by mutations in the BTK (Bruton’s tyrosine kinase) gene, are then presented in detail, followed by descriptions of the clinical manifestations and molecular basis of the less frequent autosomal recessive and autosomal dominant forms of agammaglobulinemia.  Patients’ management in terms of respiratory complications, gammaglobulin replacement therapy and the potential value of novel experimental therapeutic strategies are  discussed. The book’s closing chapters offer a comprehensive and updated description of mutations in the BTK gene, and the expression and function of BTK in cells other than B cells.

Springer International Publishing; October 2015
126 pages; ISBN 9783319227146
Read online, or download in secure PDF format
Title: Agammaglobulinemia
Author: Alessandro Plebani; Vassilios Lougaris
 
  • News
  • Contents
No entry found