The Leading eBooks Store Online 4,226,104 members ⚫ 1,419,518 ebooks

New to eBooks.com?

Learn more

mTOR Inhibition for Cancer Therapy: Past, Present and Future

mTOR Inhibition for Cancer Therapy: Past, Present and Future by Monica Mita
Buy this eBook
US$ 169.00
(If any tax is payable it will be calculated and shown at checkout.)

This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. 

Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.

Springer Paris; November 2015
300 pages; ISBN 9782817804927
Read online, or download in secure PDF format
Title: mTOR Inhibition for Cancer Therapy: Past, Present and Future
Author: Monica Mita; Alain Mita; Eric K. Rowinsky
 
  • News
  • Contents
No entry found
More Science
ISBNs
9782817804910
9782817804927