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Nonsense-Mediated mRNA Decay

Nonsense-Mediated mRNA Decay by Lynne E. Maquat
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This is the first book devoted to NMD. The rationale for such a book is the enormous information that studies of NMD have provided on the intricacies of posttrancriptional gene expression. The first five sections of the book are divided according to organism and begin with chapters on S. cerevisiae and mammals, from which most NMD data derive. Chapters within these sections discuss the two basic ways cells differentiate between a termination codon that elicits NMD and one that does not. NMD in S. cerevisiae, D. melanogaster and, probably, C. elegans and plants appears to be triggered by an abnormally long distance between a termination codon and a feature of the downstream untranslated region. In contrast, NMD in mammals is generally triggered by a sufficiently large distance between a termination codon and a downstream, post-splicing exon junction complex of proteins. The book makes clear that studies of NMD provide a unique opportunity to examine the coupling of mRNA translation and decay, and relationships between mRNP structure and function. The importance of NMD is evident from descriptions of its influence on the expression of genes that are essential for many cellular processes, including cell differentiation, cell maintenance and cell death. If justification for efforts that deepen our understanding of NMD requires a contribution toward improved health for mankind, there is the report that 12% of all mutations in the Human Gene Database are nonsense mutations. This realization suggests that understanding the various steps of the NMD pathway will be useful in the design and implementation of disease therapies. The book presents what is currently known about NMD from the perspective of a diverse group of experts in the field. It provides a one-stop source of information not only for research scientists and clinicians who actively work on NMD but also for those with peripheral or beginning interests in how nonsense codons influence gene expression.
Landes Bioscience; February 2006
275 pages; ISBN 9781587064012
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Title: Nonsense-Mediated mRNA Decay
Author: Lynne E. Maquat