One of Nature’s most important talents is evolutionary development of systems capable of molecular recognition: distinguishing one molecule from another. Molecular recognition is the basis for most biological processes, such as ligand-receptor binding, substrate-enzyme reactions and translation and transcription of the genetic code and is therefore of universal interest. Over the past four decades, researchers have been inspired by Nature to produce biomimetic materials with molecular recognition properties, by design rather than by evolution. A particularly exciting area of biomimetics is Molecular Imprinting which can be defined as process of template-induced formation of specific recognition sites (binding or catalytic) in a material where the template directs the positioning and orientation of the material’s structural components by a self-assembling mechanism. The material itself could be oligomeric (the typical example is DNA replication process), polymeric (organic MIPs and inorganic imprinted silica gels) or 2-dimensional surface assembly (grafted monolayers).
The first work on molecular imprinting was published in 1931. Since then this technology has had its “ups” and “downs” with one boom in the sixties (with a major focus on silica imprinting) and a newer period of intensive development which started in 1972 and continues today.
Essentially the current progress is a result of fundamental achievements made by more than a hundred groups working in the areas of non-covalent and reversible covalent imprinting. We believe that the time is now ripe to capture this momentum and publish a new book which will reflect the current situation in this rapidly evolving technology. We are well aware that tens of reviews have been published already on this subject. Very few of them, however, present a critical analysis of the technological aspects of molecular imprinting. We have approached leaders in the field with requests to provide their view and analysis of specific areas of design, characterization and application of these polymers.
The main body of the present book starts with chapters covering polymer design, synthesis and characterization are prepared by well-recognized experts such as Andrew Mayes and Natalia Perez-Moral, Claudio Baggiani, Naonobu Katada and Miki Niwa and Franz Dickert. The key part of the book, dedicated to MIP technology is prepared by MIP pioneers and practitioners who are now at the forefront of the practical application of MIPs: Lars Andersson, Mathias Ulbricht, Borje Sellergren, Michael Whitcombe, Alessandra Bossi, Pier Giorgio Righetti and Staffan Nilsson, Chris Allender, David Spivak, and ourselves. The last but by no means least part of the book is dedicated to often overlooked associated aspects of MIPs such as commercialization strategy and IPR, prepared by Peter Leverkus and Jeffrey McIntyre.
Landes Bioscience; May 2006
- ISBN 9781587063909
- Read online, or download in secure PDF format
- Title: Molecular Imprinting of Polymers
- Author: Sergey Piletsky (ed.); Anthony Turner (ed.)
Imprint: Landes Bioscience