Radiobiology of Glioblastoma

Recent Advances and Related Pathobiology

by Luigi Pirtoli, Giovanni Luca Gravina,

Subject categories
ISBNs
  • 9783319283036
  • 9783319283050

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. 

Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators. 


  • Springer International Publishing; June 2016
  • ISBN 9783319283050
  • Read online, or download in secure PDF format
  • Title: Radiobiology of Glioblastoma
  • Author: Luigi Pirtoli (ed.); Giovanni Luca Gravina (ed.); Antonio Giordano (ed.)
  • Imprint: Humana Press
Subject categories
ISBNs
  • 9783319283036
  • 9783319283050

In The Press

“This is a very detailed monograph on the roles of radiation, immunotherapy, genetic, epigenetic, and chemotherapy in the treatment of Glioblastoma. Biomarkers and molecular mechanisms of GBMs are discussed. … I highly recommend this book to oncologists, neurosurgeons, neurologists, and researchers involved in this perplexing baffling tumor.” (Joseph Grenier, Amazon.com, May, 2018)

About The Author

Dr. Luigi Pirtoli

Radiation Oncology Unit
Department of Medicine, Surgery and Neurosciences
University of Siena
Siena, Italy

Dr. Giovanni Luca Gravina
Department of Biology and Biotechnology
University of Pavia
Rome, Italy

Antonio Giordano
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology
Temple University
Philadelphia, PA, USA
Department of Medicine, Surgery & Neurosciences
University of Siena
Siena, Italy

Subject categories
ISBNs
  • 9783319283036
  • 9783319283050