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Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes

by David J. Hill(ed.)
Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes by David J. Hill
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Plasticity in insulin-producing cells (ƒÀ-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic ƒÀ-cells for the reversal of diabetes (by optimizing ƒÀ-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of ƒÀ-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about ƒÀ-cell plasticity: -current knowledge of pancreatic ƒÀ-cells development, and how ƒÀ-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for ƒÀ-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and ƒÀ-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of ƒÀ-cells in the quest to find a reliable therapy for diabetes.
Bentham Science Publishers; December 2016
253 pages; ISBN 9781681083650
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Title: Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes
Author: David J. Hill